This presentation explores AWS comprehensive solutions for the research community, addressing three critical challenges: meeting evolving compliance requirements like the new NIH NIST 800-171 standards, delivering scalable high-performance computing, and simplifying data management. We'll examine how the AWS Secure Research Environment (SRE) addresses complex security needs, compare managed AWS ParallelCluster Service with self-managed options, and showcase tools like the Globus S3 Connector for streamlined data handling. Join us to discover how AWS empowers researchers to focus on innovation while maintaining security, performance, and efficiency at scale.