The University of North Dakota (UND) Genomics Core has launched GenomEX 2.0, the first comprehensive and user-friendly bioinformatics platform powered by Oracle Cloud Infrastructure. This innovative platform enables biologists to seamlessly install over 13,000 bioinformatics tools, generate and execute custom code or command lines, and receive real-time guidance from an AI-based bioinformatics assistant—all through intuitive, one-click processes. To support the computing requirements for any bioinformatics tools, the platform is powered by the Oracle Cloud Infrastructure that provides fully secured (built-in security features and compliance certifications), personalized (adjustable CPU/GPU numbers & memory/storage capacity), dedicated (resources available 24/7 without any queue) and customizable (users have administrator rights) cloud-based high-performance computing environments at unbeatable pricing. Through the combined expertise of the UND Genomics Core and Oracle, GenomEX 2.0 emerges as a powerful and unique bioinformatics platform, providing every biologist with the freedom to explore biological data independently, regardless of their coding proficiency.